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Disease Gene Network

A network of disease genes linked by known disorder-gene associations

A network of disorders and disease genes linked by known disorder-gene associations, indicating the common genetic origin of many diseases. Genes associated with similar disorders show both higher likelihood of interactions between their products and higher expression profiling similarity for their transcripts, supporting the existence of distinct disease-specific functional modules. Vertex annotations contain "EntrezID", "Symbol", and "Disorder". An edge annotation EdgeWeight describes the number of genes shared each other.

(1777 vertices, 7491 edges)

Examples

Basic Examples

Retrieve the graph:

In[1]:=
ResourceData["Disease Gene Network"]
Out[1]=

Summary properties:

In[2]:=
ResourceData["Disease Gene Network", All]["Summary"]
Out[2]=

Basic Applications

Find the ID, symbol, and associated disorder of the first 10 vertices in the network:

In[3]:=
g = ResourceData["Disease Gene Network"];
In[4]:=
info = {"EntrezID", "Symbol", "Disorder"};
In[5]:=
Grid[Prepend[ Table[AnnotationValue[{g, i}, #] & /@ info, {i, VertexList[g][[;; 10]]}], info], Sequence[ Frame -> All, Background -> {None, {LightGray, {LightYellow}}}, Alignment -> Left, Spacings -> 1.5]]
Out[5]=

Wolfram Research, "Disease Gene Network" from the Wolfram Data Repository (2019)  

Data Resource History

  • Date Created:

Source Metadata

  • Citation:
    • Goh K-I, Cusick ME, Valle D, Childs B, Vidal M, Barabási A-L (2007), The Human Disease Network, Proc Natl Acad Sci USA 104:8685-8690

Data Downloads

Publisher Information

  • Prepared for the Wolfram Data Repository By: Wolfram
  • Publisher of Record: Wolfram Research